Age-Related Macular Degeneration

The value of Age Related Macular Degeneration has clearly stood the test of time, but progress in both basic and clinical ophthalmology has been relentless, thereby mandating the need for an updated book. The physicians, scientists, and patients who read this Third Edition will be reassured that this markedly enhanced edition has met the challenge of providing new information that is both intellectually and clinically valuable. Dr. Lim has again chosen expert authors for the important topics in this stimulating compendium. Chapters are devoted to the following: pathophysiology and epidemiology of age related macular degeneration (AMD); clinical features of AMD; imaging techniques; and medical therapy for both non-neovascular AMD and neovascular AMD. Both clinically validated and experimental therapies are well described, including rehabilitation technology (a highly important topic that is often overlooked in the management of patients with AMD). Jennifer I. Lim, M.D. is a Professor of Ophthalmology, Department of Ophthalmology; Director of the Retina Service; Marion H. Schenk, Esq. Chair in Ophthalmology for Research of the Aging Eye , at the University of Illinois at Chicago. Dr Lim has contributed to over 90 courses, and has published over 200 academic papers, contributed to over 20 book chapters and published 4 books in total. She has given over 150 presentations at scientific meetings and has been invited to over 130 lectures/ visiting professorships. Dr Lim is a reviewer for a number of academic journals including the American Journal of Ophthalmology, Retina, and the British Journal of Ophthalmology. She is currently a Committee member for the Macula Society, American Society of Retinal Specialists, and American Academy of Ophthalmology. Recent Awards: •Marion H. Schenk, Esq., Chair in Ophthalmology for Research of the Aging Eye, 2010 •Best Doctors in America 2010-2011 (initially and continuously selected since 1994) Key features of this new edition •Over 200 clinical photographs and illustrations (many in full colour) •An in depth review and analysis of the management of dry and wet AMD (medical and surgical therapies) •Research advancements that have resulted in novel therapies •Strategies to prevent the progression of non-exudative AMD •Summary of studies and results from current clinical trials •A collaboration of world renowned experts in the field- over 75 contributors 13 new chapters include •New genetics and treatment chapter will cover the responses of different variants to treatment. •'Oxidative Stress' is moving along quickly as a new target for therapy. This is important in the pathophysiology for AMD and CNV (choroidal neovascularization- a common symptom of wet AMD). •'Polypoidal and RAP chapters' are included as more info. Warrants separate chapters of these variants of AMD. •How to analyze OCT will cover the analysis software and other programs that help in managing patients. •Microperimetry and psychophysical testing will cover new ways to track geographic atrophy progression (includes newly uncovered data). •Non-VEGF pathways will cover complement paths, nicontinic etc – important new treatment paths. •Radiation and Steroid chapters will address new treatments that help in CNV management. •Retinal stem cells will cover new information and potential avenues of future treatment. •Combination therapy Features Includes over 200 clinical photographs and illustrations (many in full colour) Provides an in depth review and analysis of the management of dry and wet AMD (medical and surgical therapies) Includes a research advancements that have resulted in novel therapies and strategies to prevent the progression of non-exudative AMD Summarizes studies and results from current clinical trials Table of Contents Part I: Pathophysiology and epidemiology of AMD 1.Histopathology of Age-Related Macular Degeneration 2.Immunology of Age-Related Macular Degeneration 3.Genetics of Age-Related Macular Degeneration 4.Choroidal Neovascularization: VEGF Pathways (NEW) 5.Risk factors for Age-Related Macular Degeneration and Choroidal Neovascularization 6.Oxidative Stress (NEW) Part II: Clinical Features of AMD 7.Geographic Atrophy 8.Non-Neovascular Age-Related Macular Degeneration 9.Neovascular Age-Related Macular Degeneration 10.Polypoidal Choroidal Vasculopathy (NEW) 11.Variants of Neovascular Age-related Macular Degeneration: Type 3 Neovascularization (Intra-retinal Neovascularization or Retinal Angiomatous Proliferation) (NEW) Part III: Imaging Techniques for the Clinical Evaluation of AMD 12.Fluorescein Angiography in Age-related Macular Degeneration (NEW) 13.Indocyanine Green Angiography in Age-Related Macular Degeneration 14.Optical Coherence Tomography in the Evaluation of Age-Related Macular Degeneration 15.How to Analyze OCT images for Management of Neovascular AMD 16.Fundus Autofluorescence Imaging in Age-Related Macular Degeneration 17.Microperimetry and Psychophysical Testing to Aid in Determination of Progression of AMD (NEW) Part IV: Current and Experimental Medical Treatment for Neovascular AMD 18.Laser Photocoagulation for Choroidal Neovascularization 19.Anti-VEGF drugs and Clinical trials 20.Non-VEGF Related Anti-Angiogenesis Pathways for Treatment of AMD (NEW) 21.Radiation Therapy Treatment in Age-Related Macular Degeneration 22.Combination Therapy for AMD (NEW) 23.Photodynamic Therapy for Neovascular AMD 24.Photocoagulation of AMD-Associated CNV Feeder Vessels 25.Macular Translocation and Other Surgical Treatments (NEW) Part V: Current and Experimental Medical Treatment for Non-Neovascular AMD and Geographic Atrophy 26.Prophylactic Treatment: The AREDS Study Results (NEW) 27.Visual Cycle Modulation (NEW) 28.Cellular Transplantation for Advanced Age-Related Macular Degeneration (NEW) 29.Novel Therapeutic Interventions: Stem Cell (NEW) Part VI: Rehabilitation of the Eye 30.Clinical Considerations for Visual Rehabilitation 31.Visual Prostheses for Age-Related Macular Degeneration Part VII: Development of Research Protocols in AMD 32.Clinical Research Trials