Accounting for more than 40% of all heart failure problems, diastolic heart failure is a complex and often difficult diagnosis with rapidly evolving diagnostic management protocols. Diastology: Clinical Approach to Heart Failure with Preserved Ejection Fraction, 2nd Edition, brings you up to date and equips you to successfully diagnose and manage even the most challenging incidences of diastolic heart failure and their comorbidities. It incorporates the latest guidelines for the diagnostic evaluation of the patient with suspected or known diastolic dysfunction, provides a comprehensive review of clinical conditions associated with heart failure with preserved ejection fraction, and describes the complementary role of imaging modalities and novel therapeutic approaches.
Table of Contents:
Part I: Basic Determinants of Diastolic Function
Molecular, Gene, and Cellular Mechanis
Pathophysiology of Heart Failure With a Preserved Ejection Fraction: Measurements and Mechanisms Causing Abnormal Diastolic Function
Role of the Pericardium in Diastolic Dysfunction
Left Atrial Function: Basic Physiology
Physical Determinants of Diastolic Flow
Ventricular–Arterial Interaction in Patients With Heart Failure and a Preserved Ejection Fraction
Part II: Diagnosis of Heart Failure With Preserved Ejection Fraction
General Principles, Clinical Definition, Epidemiology, and Pathophysiology
Invasive Hemodynamic Assessment in Heart Failure With Preserved Ejection Fraction
Two-Dimensional and Doppler Evaluation of Left Ventricular Filling, Including Pulmonary Venous Flow Velocity
Evaluation of Diastolic Function by Tissue Doppler, Strain, and Torsion Analysis
Color M-mode Doppler
Assessment of Left Atrial Size and Function
Evaluation of Intracardiac Filling Pressures
Evaluation of Right Ventricular Diastolic Function
Evaluation of Diastolic Function by Cardiac Magnetic Resonance Imaging
Evaluation of Diastolic Function by Radionuclide Techniques
Diastolic Echocardiographic Examination
Diastology Stress Test
ASE/EACVI Diastolic Guidelines: Strength and Limitations
Part III: Cardiac Diseases With HFpEF
Hypertension and Its Relation to Heart Failure With a Preserved Ejection Fraction
Valve Disease
Stage D Heart Failure With Preserved Ejection Fraction, Heart Transplantation, and Mechanical Circulatory Support
Primary Restrictive, Infiltrative, and Storage Cardiomyopathies
Coronary Artery Disease
Hypertrophic Cardiomyopathy
Pericardial Diseases: Constrictive Pericarditis and Pericardial Effusion
Diastolic Function in Children and in Children With Congenital Heart Disease
Diabetes Mellitus
Part IV: Emerging Topics in HFpEF
Global and Regional Systolic Function of the Left Ventricle
Chronotropic Incompetence and Pacing in HPEF Heart Failure with Preserved Ejection Fraction
Aging and Heart Failure With Preserved Ejection Fraction
Perioperative Assessment of Diastolic Function
Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
Part V: Treatment of HFpEF
General Treatment of Heart Failure With Preserved Ejection Fraction and Randomized Trials
Echo-Based Approach to the Management of Heart Failure With Preserved Ejection Fraction
Future Therapies in HFpEF
Part VI: Cases of Diastolic Heart Failure
Cases of Diastolic Heart Failure
