Imaging Biomarkers in Epilepsy

Epilepsy is a prevalent and serious neurological disorder. This vital textbook addresses the role of neuroimaging as a unique tool to provide in vivo biomarkers aimed at furthering our understanding of causes and consequences of epilepsy in a day-to-day clinical context. Unique in its approach, this translational book presents a critical appraisal of advanced pre-clinical biomarkers that allows capturing epileptogenesis at molecular, cellular, and neuronal system levels. The book is divided into four sections. Part I includes a series of chapters focused on imaging of early disease stages. Part II discusses lesion detection and network analysis methods. Part III focuses on imaging methods used to predict response to antiepileptic drugs and surgery. Finally, Part IV presents imaging techniques used to evaluate disease consequence.

    Places emphasis on clinical relevance and applications throughout, with a dedicated final section in each chapter
    Provides a wide-ranging focus including neuroimaging in paediatric and adult patients, and epilepsy surgery, relevant to all practitioners
    Situated in real-life context, addressing practical applications on the causes and consequences of epilepsy at molecular, cellular, and neuronal system levels

Table of Contents

Preface
Dedication
Part I. Imaging the Development and Early Phase of the Disease:
1. Imaging biomarkers for febrile status epilepticus and other forms of convulsive status epilepticus Rodney Scott
2. Experimental MRI approaches to study post-traumatic epilepsy Olli Gröhn and Alejandra Sierra
3. Imaging biomarkers of acquired epilepsies Marian Galovic and Matthias Koepp
4. Imaging and cognition in children with new onset epilepsies Kevin Dabbs, Camille Garcia-Ramos, Darren Jackson, Jack Lin, Sam Bobholz, Dace Almane, Jana Jones, Mike Seidenberg and Bruce Hermann
5. Imaging genetics for benign mesial temporal lobe epilepsy Antonio Gambardella and Angelo Labate
Part II. Modeling Epileptogenic Lesions and Mapping Networks:
6. Computational neuroimaging of epilepsy Seok-Jun Hong, Min Liu, Ravnoor Gill, Edward Hogan, Neda Bernasconi, Andrea Bernasconi
7. Imaging white matter pathology in epilepsy Min Liu, Luis Concha, Boris C. Bernhardt, Neda Bernasconi and Andrea Bernasconi
8. Epilepsy network remodelling in epileptic disorders through neuroimaging Lorenzo Caciagli, Boris C. Bernhardt, Andrea Bernasconi and Neda Bernasconi
9. Mapping metabolism and inflammation in epilepsy Csaba Juhász and Sandeep Mittal
10. Inter-ictal and Ictal brain network changes in focal epilepsy Mangor Pedersen, Amir Omidvarnia and Graeme D. Jackson
11. Ictal events imaged through SPECT Elson L. So, Vlastimil Sulc, Gregory Worrell and Benjamin H. Brinkmann
12. Imaging thalamo-cortical circuitry in generalised epilepsies Fenglai Xiao and Lorenzo Caciagli
Part III. Predicting the Response to Therapeutic Interventions:
13. Prevention of epileptogenesis in animal models Asht Mangal Mishra and Hal Blumenfeld
14. Imaging of mechanisms of drug resistance in experimental models of epilepsy Jens P. Bankstahl and M. Bankstahl
15. Biomarkers of drug-response and pharmaco-resistance Britta Wandschneider, Maria Feldmann and Matthias Koepp
16. Predicting the outcome of surgical interventions for epilepsy using imaging biomarkers Clarissa Lin Yasuda, Ana Carolina Coan, Marina K. Alvim and Fernando Cendes
Part IV. Mapping Consequences of the Disease:
17. Imaging neural excitability and networks in genetic absence epilepsy models Grygoriy Tsenov, Giuseppe Bertini, Michele Pellitteri, Elena Nicolato, Pasquina Marzola, Paolo Francesco Fabene and Gilles van Luijtelaar
18. Network excitability and cognition in the developing brain William David Gaillard and Madison M. Berl
19. Imaging co-morbidities in epilepsy: depression William H. Theodore
20. Tracking epilepsy disease progression with neuroimaging Boris C. Bernhardt, Ana Carolina Coan, Lorenzo Caciagli, Andrea Bernasconi and Neda Bernasconi
21. Imaging biomarkers to study cognition in epilepsy Silvia B. Bonelli and John S. Duncan
Index.

Andrea Bernasconi M.D. is Professor of Neurology and epileptologist, and Professor in the Integrated Program in Neuroscience at McGill University. He is founding Director of the Neuroimaging of Epilepsy Laboratory, one of the core labs of the McConnell Brain Imaging Centre at the Montreal Neurologiocal Institute, Montreal, Canada. His research focuses on neuroimaging of malformations of cortical development, particularly the design of computerized MRI analysis methods to automatically model pathological brain morphology.

Neda Bernasconi, M.D. is Professor in the Integrated Program in Neuroscience at McGill University and co-Director of the Neuroimaging of Epilepsy Laboratory at the McConnell Brain Imaging Centre of the Neurological Institute, McGill University, Montreal, Canada. She is a world-renowned expert in advanced imaging of seizure disorders, particularly those related to the limbic system. The goal of her research is to develop cutting-edge neuroimaging methods and combine them with statistical learning in search for epilepsy biomarkers.

Matthias Koepp M.D. is Professor of Neurology at the University College London, Institute of Neurology and Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London. He takes a particular interest in generalized epilepsies, epilepsy and co-morbidities (depression). His research is focused on mechanisms of initiation and termination of epileptic seizures, using molecular and functional imaging methods. In particular, his work aims to clarify, experimentally and clinically, the mechanisms, causes and associations of cerebral damage consequent upon epileptic seizures and epilepsy.