Neonatal Hematology

Neonatal hematology is a fast-growing field, and the majority of sick neonates will develop hematological problems. This is an essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values. Chapters have been thoroughly revised according to the latest advances in the field for this updated third edition. Topics discussed include erythrocyte disorders, platelet disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Coverage of oncological issues has been expanded to two separate chapters on leukemia and solid tumors, making information more easily accessible. Approaches to identifying the cause of anemia in a neonate are explained, with detailed algorithms provided to aid clinicians in practice. Covering an important hematologic niche with an ever increasing amount of specialized knowledge, this book is a valuable resource for hematologists, neonatologists and pediatricians.

    Includes reference ranges for hematological values according to gestational and postnatal age, aiding quick and accurate treatment of patients
    Describes a practical approach to common and rare hematological problems in neonates
    Focuses on problem-solving, including the interpretation of common blood tests, transfusions, anemias and platelet problems

Contents

Foreword James Stockman III
Preface Pedro A. de Alarcon, Eric Werner, Robert D. Christensen and Martha Sola-Visner
Part I. Developmental Hematology:
1. A historical review Howard Pearson (deceased)
2. Hematopoiesis Amber M. D'Souza, Pedro de Alarcon and Mervin C. Yoder
3. The development of the human immune system Amy O'Connell, Angela Rivers and William B. Slayton
Part II. Bone Marrow Failure and Immune Disorders:
4. Bone marrow failure syndromes Amy Geddis, Meera Srikanthan and Katie Bergstrom
5. Immunodeficiency diseases of the neonate Julie J. Kim-Chang, James L. Wynn, Matthew A. Saxonhouse and John W. Sleasman
Part III. Erythrocyte Disorders:
6. Newborn genetic screening for blood disorders Parul Rai, Ewelina K. Mamcarz and Jane Hankins
7. A guide to identifying the cause of anemia in a neonate Robert D. Christensen
8. Anemia of prematurity and indications for erythropoietin therapy Pamela Kling
9. Hemolytic disease of the fetus and newborn Mary Beth Ross, Stephen P. Emery, Pedro de Alarcon and Jon F. Watchko
10. Neonatal hemolysis Bertil Glader and Aditi Kamdar
11. Polycythemia and hyperviscosity in the newborn Ted Rosenkrantz and William Oh
Part IV. Platelet Disorders:
12. Approach to thrombocytopenia Emöke Deschmann and Martha Sola-Visner
13. Acquired thrombocytopenias Patricia E. Davenport and Martha Sola-Visner
14. Fetal and neonatal alloimmune and isoimmune thrombocytopenias W. Beau Mitchell and James B. Bussel
15. Congenital thrombocytopenias and thrombocytopathies Amy Geddis and Pedro de Alarcon
Part V. Leucocyte Disorders:
16. Eosinophils and neutrophils Kurt Schibler and Robert D. Christensen
17. Functional phagocyte disorders in the neonate Thomas F. Michniacki and Kelly Walkovich
Part VI. Hemostatic Disorders:
18. Bleeding disorders Manuela Albisetti and Paul Monagle
19. Neonatal thrombosis Julie Kim-Chang, James L. Wynn, Matthew A. Saxonhouse and John W. Sleasman
Part VII. Neonatal Transfusion Medicine:
20. Transfusion practices Cyril Jacquot, Yunchuan D. Mo and Naomi L. Luban
Part VIII. Neonatal Oncology:
21. Neonatal leukemia Erin M. Guest, Catherine Garnett, Irene Roberts and Alan S. Gamis
22. Neonatal and perinatal solid tumors Kevin F. Ginn, Jaszianne A. Tolbert, Glenson Samuel, J. Allyson Hays and Alan S. Gamis
Part IX. Miscellaneous:
23. Disorders of the feto-maternal unit Eric Werner, Nancy Chescheir and Randall Fisher
24. Reference intervals in neonatal hematology Robert D. Christensen.

Pedro A. de Alarcón, is William H. Albers Professor and Head, Department of Pediatrics, University of Illinois College of Medicine, Peoria, IL, USA.

Eric J. Werner is Professor of Pediatrics at the Eastern Virginia Medical School and Division Director of the Division of Pediatric Hematology/Oncology, Children's Hospital of the King's Daughters, Norfolk, VA, USA.

Robert D. Christensen is Director of Neonatology Research at Intermountain Healthcare and Professor of Pediatrics, University of Utah HEALTH, Salt Lake City, UT, USA.

Martha C. Sola-Visner is Director of the Newborn Medicine Clinical Research Program at Boston Children's Hospital and Associate Professor of Pediatrics, Harvard Medical School, Boston, MA, USA.