This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases.
Provides readers with knowledge about the broad field of drug resistance
Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases
Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Table of contents
List of Contributors
Preface
Part I: Current antibiotics and their mechanism of action
Chapter 1: Resistance to aminoglycosides: glycomics and the link to the Human gut microbiome
Chapter 2: Mechanisms of action and of resistance to quinolones
Chapter 3: Betalactams
Chapter 4: Glycopeptide antibiotics: Mechanism of action and recent developments
Chapter 5: Current macrolide antibiotics and their mechanisms of action
Part II: Mechanism of antibiotic resistance
Chapter 6: Impact of key and secondary drug resistance mutations on structure and activity of β-lactamases
Chapter 7: Acquired resistance from gene transfer
Chapter 8: Antimicrobial efflux pumps
Chapter 9: Bacterial persistence in biofilms and antibiotics: mechanisms involved
Part III: Socio-economical perspectives and impact of AR
Chapter 10: Sources of antibiotic resistance – zoonotic, human, environment
Chapter 11: Antibiotic Resistance – immunity, acquired resistance: Evolution of antimicrobial resistance among extended-spectrum β-lactamases and Carbapenemases in Klebsiella pneumoniae and Escherichia coli
Chapter 12: Prevalence of AR – world map: Overview of Extended-Spectrum-β-Lactamase and Carbapenemase -Producing Enterobacteriaceae in Food-Producing Animals in Europe. A Impact on Public Health?
Part IV: Therapeutic Strategy for overcoming AR
Chapter 13: AR mechanism based drug design
Chapter 14: Antibiotics from natural sources
Chapter 15: Bacteriophage proteins as antimicrobials to combat antibiotic resistance
Chapter 16: Antibiotics modification addressing resistance
Chapter 17: Sensitizing agents to restore antibiotic activity
Chapter 18: Repurposing antibiotics to treat resistant gram-negative pathogens
Chapter 19: Non-traditional medicines for treatment of AR
Chapter 20: Therapeutic options for treatment of infections by pathogenic biofilms
Part V: Strategies to prevent the spread of AR
Chapter 21: Rapid analytical methods to identify AR bacteria
Chapter 22: Effective methods for disinfection and sterilization
Chapter 23: Strategies to prevent the spread of antibiotic resistance: understanding the role of antibiotics in nature and their rational use
Part VI: Public policy
Chapter 24: Strategies reduce or eliminate resistant pathogen in the environment
